Stuart Derbyshire Assistant Professor, Anesthesiology and Critical Care Medicine University of Pittsburgh Phone: (412) 647-9711 Fax: (412) 647-9800 Email: Derbyshiresw@anes.upmc.edu

Ph.D. Research Interests My work focuses on the central mechanisms of pain and the abnormalities that occur in chronic pain disorders. Using functional imaging, we have demonstrated that the central processing of pain extends well beyond primary sensory cortex - the classical projection of the spinothalamic tract. Regions of activation during pain include the insular, anterior cingulate, parietal, secondary somatosensory and prefrontal cortices. This large "matrix" of regions responding to pain reflects the multidimensional nature of pain experience, which includes sensory, affective and cognitive components. We are currently studying the impact of exaggerating or distorting each component of pain on the pattern of central activity and are gradually uncovering the abnormalities of central processing in patients with intractable functional pain disorder. Functional disorders currently under investigation include non-specific chronic low back pain and irritable bowel syndrome. Recently we have begun to use hypnosis to modulate pain experience. In a group of normal volunteers we were able to generate entirely “psychogenic” pain, i.e., noxious experience in the absence of any noxious stimulus. This experience produced very similar neuronal activity to that during an actually delivered noxious stimulus. In future work we expect to use hypnosis to provide the reverse effect, analgesia to an actually present stimulus. Recent Publications Derbyshire SWG. Fetal pain: An infantile debate. Bioethics 2001; 1: 77-84. Derbyshire SWG. Principles of Behavioral and Cognitive Neurology, 2nd Edition [review]. Contemporary Psychology – APA Review of Books 2001; 46: 590-593. Derbyshire SWG. The Execution of Timothy McVeigh: Must See TV? British Medical Journal 2001; 322:1254. Derbyshire SWG. Genetics in Medicine: Real Promises Unreal Expectations. British Medical Journal 2001; 322: 1069. Derbyshire SWG. Designer Babies: Where Should We Draw the Line? British Medical Journal 2002; 325: 974. Derbyshire SWG. The Tyranny of Health: Doctors and the Regulation of Lifestyle. British Medical Journal 2001; 322: 305. Derbyshire SWG, Jones AKP, Creed F, Starz T, Meltzer CC, Townsend DW, Peterson AM, Firestone L. Cerebral responses to noxious thermal stimulation in chronic low back pain patients and normal controls. Neuroimage 2002; 16: 158-168. Derbyshire SWG, Nichols TE, Firestone L, Townsend DW, Jones AKP. Gender differences in patterns of cerebral activation during equal experience of painful laser stimulation. Journal of Pain 2002; 3: 401-411. Jones AKP, Kulkarni B, Derbyshire SWG. Functional imaging of pain perception. Current Rheumatology Reports 2002; 4: 329-333. Derbyshire SWG. Why Animal Rights are Wrong. In, Animal Experiments: Good or Bad? E. Lee, Ed. Hodder & Stoughton, 2002. Berman S, Chang L, Suyenobu B, Derbyshire SW, Stains J, Fitzgerald L, Mandelkern M, Hamm L, Vogt B, Naliboff BD, Mayer EA. Condition specific deactivation of brain regions by 5-HT3 receptor antagonist alosetron. Gastroenterology 2002; 123: 969-977. Derbyshire SWG. Measuring our natural painkiller. Trends in Neuroscience 2002; 25: 65-66. Bentley DE, Derbyshire SWG, Youell PD, Jones AKP. Caudal cingulate cortex involvement in pain processing: an inter-individual laser evoked potential source localisation study using realistic head models. Pain 2003; 102: 265-271. Derbyshire SWG. Review and meta-analysis of neuroimaging data reveals differential activation from upper and lower gastrointestinal distension. American Journal of Gastroenterology 2003; 98: 12-20.