Michael F. Pogue-Geile Associate Professor, Psychology and Psychiatry University of Pittsburgh Phone: (412) 624-8818 Fax: (412) 624-5407 Email: mfpg@pitt.edu

Ph.D., Indiana University Research Interests Dr. Pogue-Geile's research focuses on understanding the nature and development of genetic susceptibility to schizophrenia and the causes and structure of individual differences in neuropsychological functioning in the general population. To this end, his laboratory is engaged in studies of behavioral and neuropsychological abnormalities among relatives of schizophrenic patients. In addition, because of the developmental nature of schizophrenia, longitudinal studies of patients are also conducted. To better inform these studies of neuropsychological functioning in clinical populations, Dr. Pogue-Geile is also investigating genetic influences on neuropsychological functioning in the general population during young adulthood in a study of twins using both biometric approaches and genetic association studies with polymorphisms in genes relevant to the dopamine system. Research and training opportunities in Dr. Pogue-Geile's laboratory include application of neuropsychology and genetic methodologies to understanding the development of susceptibility to schizophrenia. Students can receive experience in a range of neuropsychological and psychopathological assessments as applied to both normal and clinical populations, as well as experience in quantitative behavior genetic methods and genetic association and linkage methods using genetic polymorphisms. Recent Publications Pogue-Geile, M.F., Chowdari, K., Wood, J., Thompson, J., Nimgaonkar, V. (2003). Heterogeneity of schizophrenia: A genetic association study of variation in cognitive function and chromosome 13 markers. Schizophrenia Research, 60, 89. Thompson, J.L., Pogue-Geile, M.F., & Grace, A.A. (In press). Developmental pathology, dopamine, and stress: A model for the age of onset of schizophrenia symptoms. Schizophrenia Bulletin. Pogue-Geile, M.F. (2003). Spectrum Disorders. In Encyclopedia of the Human Genome, Nature Publishing Group. Pogue-Geile, M.F., & Gottesman, I.I. (In press). Schizophrenia: Study of a genetically complex phenotype. In B.C. Jones & P. Mormède (Eds.), Neurobehavioral Genetics: Methods and applications (2nd ed). Boca Raton, FL: CRC Press. Thompson, J.L., Watson, J.R., Steinhauer, S.R., Goldstein, G., & Pogue-Geile, M.F. (In press) Indicators of genetic liability to schizophrenia: A sibling study of neuropsychological performance. Schizophrenia Bulletin. MacDonald, A.W., Pogue-Geile, M.F., Johnson, M.K., & Carter, C.S. (2003). A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Archives of General Psychiatry, 60, 57-65. Pogue-Geile, M.F., Manuck, S., Ferrell, R., & Debski, T. (2001). Cognitive function and dopamine transporter (DAT) genetic polymorphisms: A twin and genetic association study. Behavior Genetics, 31, 464. MacDonald, A., Pogue-Geile, M., Debski, T., & Manuck, S. (2001). Genetic and environmental influences on schizotypy: A community-based twin study. Schizophrenia Bulletin, 27, 47-58. Craver, J.C., & Pogue-Geile, M.F. (1999). Liability to schizophrenia: A sibling study of negative symptoms. Schizophrenia Bulletin, 25, 827-839.