Ph.D., University of Colorado at Boulder
Traumatic brain injury (TBI) is a serious medical problem affecting approximately 1.5 to 2 million people in the United States each year. An estimated 100,000 endure long-term disabilities that require rigorous, lengthy, and costly medical and rehabilitative care. My research interests include neurobehavioral recovery and learning after experimental traumatic brain injury (TBI). Therapeutic strategies that include pharmacotherapy and environmental enrichment are utilized alone or in combination in an attempt to restore function and/or attenuate TBI-induced deficits. Another interest is the evaluation of pharmacological agents that may hinder the recovery process after TBI (e.g., antipsychotics). Recent therapeutic approaches in the laboratory include moderate hypothermia, antioxidants, dopaminergic and 5-HT1A receptor agonists, and acetylcholinesterase inhibitors. The long-term goals of the laboratory are to develop therapies that can be translated from the bench to bedside to facilitate functional recovery after human TBI and to elucidate potential mechanisms for the observed effects. Additionally, the evaluation of therapies shown to benefit outcome in adult models of TBI are being investigated in pediatric models. My laboratory is located in the Safar Center for Resuscitation Research where ample collaboration exists between brain experts from the Departments of Physical Medicine & Rehabilitation, Neurological Surgery, and Critical Care Medicine. This wealth of knowledge, which includes, but is not limited to, numerous behavioral assessments as well as a variety of molecular and immunocytochemistry techniques, is available to graduate students whose interests are consistent with the overall goals of the laboratory.
Dr. Kline’s publications on PubMed http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Kline+AE%5BAuthor%5D
Link to Department of Physical Medicine & Rehabilitation http://www.rehabmedicine.pitt.edu/content.asp?id=805