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CNBC's 20th Anniversary Celebration

October 17–18, 2014





Exhibition October 10 – 26, 2014


work in and around the brain

Curated by Patricia Maurides in collaboration with the Center for the Neural Basis of Cognition




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Kline, Anthony


Associate Professor, Phys Med & Rehab and Psychology
Associate Director of Rehabilitation Research, Safar Center for Resuscitation Research

University of Pittsburgh

Phone: 412-383-2806

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Ph.D., University of Colorado at Boulder


Research Interests

Traumatic brain injury (TBI) is a serious medical problem affecting approximately 1.5 to 2 million people in the United States each year. An estimated 100,000 endure long-term disabilities that require rigorous, lengthy, and costly medical and rehabilitative care. My research interests include neurobehavioral recovery and learning after experimental traumatic brain injury (TBI). Therapeutic strategies that include pharmacotherapy and environmental enrichment are utilized alone or in combination in an attempt to restore function and/or attenuate TBI-induced deficits. Another interest is the evaluation of pharmacological agents that may hinder the recovery process after TBI (e.g., antipsychotics). Recent therapeutic approaches in the laboratory include moderate hypothermia, antioxidants, dopaminergic and 5-HT1A receptor agonists, and acetylcholinesterase inhibitors. The long-term goals of the laboratory are to develop therapies that can be translated from the bench to bedside to facilitate functional recovery after human TBI and to elucidate potential mechanisms for the observed effects. Additionally, the evaluation of therapies shown to benefit outcome in adult models of TBI are being investigated in pediatric models. My laboratory is located in the Safar Center for Resuscitation Research where ample collaboration exists between brain experts from the Departments of Physical Medicine & Rehabilitation, Neurological Surgery, and Critical Care Medicine. This wealth of knowledge, which includes, but is not limited to, numerous behavioral assessments as well as a variety of molecular and immunocytochemistry techniques, is available to graduate students whose interests are consistent with the overall goals of the laboratory.


Recent Publications

  • Kline AE, McAloon RL, Henderson KA, Bansal UK, Ganti BM, Ahmed RH, Gibbs RB, Sozda CA. Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury. J Neurotrauma, 27:2021-2032, 2010.
  • de Witt BW, Ehrenberg KM, McAloon RL, Panos AH, Shaw KE, Raghavan PV, Skidmore ER, Kline AE. Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury. Neurorehabil Neural Repair, 25:343-350, 2011.
  • Cheng JP, Shaw KE, Monaco CM, Hoffman AN, Sozda CN, Olsen AS, Kline AE. A relatively brief exposure to environmental enrichment after experimental traumatic brain injury confers long-term cognitive benefits. J Neurotrauma, 29:2684-2688, 2012.
  • Shaw KE, Bondi CO, Light SH, Massimino LA, McAloon RL, Monaco CM, Kline AE. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. J Neurotrauma, 30:557-564, 2013.
  • Monaco CM, Mattiola VV, Folweiler KA, Tay JK, Yelleswarapu NK, Curatolo LM, Matter AM, Cheng JP, Kline AE. Environmental enrichment-mediated benefits in female rats after brain trauma further supports this paradigm as a preclinical model of neurorehabilitation. Exp Neurol., (e-Pub, 2013).



Additional Links

Dr. Kline’s publications on PubMed

Link to Department of Physical Medicine & Rehabilitation