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CNBC's 20th Anniversary Celebration

October 17–18, 2014





Exhibition October 10 – 26, 2014


work in and around the brain

Curated by Patricia Maurides in collaboration with the Center for the Neural Basis of Cognition




Featuring investigations, translations and reflections by artists and neuroscientists.

Upcoming Events

09-03 4:00pm - 5:00pm
Pgh/London Consortium Lecture

09-04 12:00pm - 1:30pm
CBDR Seminar, Loss Aversion in the Field and Lab

09-04 2:30pm - 3:30pm
Pitt EpiBrain Neuroimaging Journal Club

09-08 12:00pm - 1:00pm
Guest speaker, David C Glahn, Ph.D

09-12 9:30am - 10:30am
Pitt Psych Research Seminar

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Yu, Byron

yu Assistant Professor, Electrical and Computer Engineering, Biomedical Engineering
Carnegie Mellon University

Phone: (412) 268-9658

Individual Website:

Ph.D., Stanford University

Research Interests

Our group seeks to elucidate how large populations of neurons process information, from encoding sensory stimuli to guiding motor actions.  Most neurophysiological studies to date involve studying one neuron at a time. Although one neuron can be informative about the sensory stimulus or motor action, it often doesn't tell the full story. While this provides the motivation for looking across a neural population, the heterogeneity of the activity of different neurons can be baffling.

We have two major aims:

(1) To develop and apply novel signal processing and machine learning algorithms to explain the high-dimensional structure and timecourse of neural population activity.

(2) To apply this knowledge to the design of next-generation biomedical devices that interface with large populations of neurons in increasingly sophisticated ways.

The work is at the intersection of signal processing / machine learning, biomedical engineering, and basic neuroscience.

Recent Publications

  • Churchland, MM, Yu, BM,  Cunningham, JP, Sugrue, LP, Cohen, MR, Corrado, GS, Newsome, WT, Clark, AM, Hosseini, P, Scott, BB, Bradley, DC, Smith, MA, Kohn, A, Movshon, JA, Armstrong, KM, Moore, T, Chang, SW, Snyder, LH, Priebe, NJ, Finn, IM, Ferster, D, Ryu, SI, Santhanam, G, Sahani, M, Shenoy, KV: Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci, 2010. In press.
  • Santhanam, G, Yu, BM, Gilja, V, Ryu, SI, Afshar, A, Sahani, M, Shenoy, KV: Factor-analysis methods for higher-performance neural prostheses. J Neurophysiol 102: 1315-1330, 2009.
  • Yu, BM, Cunningham, JP, Santhanam, G, Ryu, SI, Shenoy, KV, Sahani, M: Gaussian-process factor analysis for low-dimensional single-trial analysis of neural population activity. J Neurophysiol 102: 614-635, 2009.
  • Churchland, MM, Yu, BM, Sahani, M, Shenoy, KV: Techniques for extracting single-trial activity patterns from large-scale neural recordings. Curr Opin Neurobiol 17(5): 609-618, 2007.
  • Yu, BM, Kemere, C, Santhanam, G, Afshar, A, Ryu, SI, Meng, TH, Sahani, M, Shenoy, KV: Mixture of trajectory models for neural decoding of goal-directed movements.  J Neurophysiol 97: 3763-3780, 2007.
  • Santhanam, G, Ryu, SI, Yu, BM, Afshar, A, Shenoy, KV: A high-performance brain-computer interface. Nature 442: 195-198, 2006.
  • Churchland, MM, Yu, BM, Ryu, SI, Santhanam, G, Shenoy, KV: Neural variability in premotor cortex provides a signature of motor preparation. J Neurosci 26(14): 3697-3712, 2006.