M.D., Washington University School of Medicine
I am a behavioral child neurologist. My focus for the past 20 years has been the investigation of the cognitive, neurologic, and neural basis of autism. Most recently, we have added investigation of the family genetics of autism. This research has led to evidence of autism as a selective disorder of complex information processing with sparing of simple information processing. Eye movement studies have provided evidence of selective involvement of neocortical systems and of reduced computational capacity. Structural imaging studies have revealed evidence of over development of local brain circuitry and underdevelopment of longer distance connections. MRS studies have provided evidence of undersynthesis and increased degradation of brain membranes and of disjointed temporal development of brain membranes.
Future research will continue in these areas with a focus on neural systems organization, neuronal organizational events, and new areas of cognition such as prototype formation, facial recognition, and social cognition. This work is being done in collaboration with Drs. Bernie Devlin, Bill Eddy, Gerald Goldstein, Marcel Just, Marlene Behrmann, Mark Strauss, Bea Luna, and John Sweeney, and Diane Williams.
- Scherf KS, Luna B, Minshew NJ, Behrmann M: Location, location, location: Alterations in the functional topography of face- but not object- or place-related cortex in adolescents with autism. Front Hum Neurosci 4:26, 2010. PMCID: PMC2904054
- Dinstein I, Thomas C, Humphreys K, Minshew NJ, Behrmann M, Heeger DJ: Normal movement-selectivity in autism. Neuron 66(3): 461-9, 2010. PMCID: PMC2872627
- Best CA, Minshew NJ, Strauss MA: Gender Discrimination of Eyes and Mouths by Individuals with Autism. Autism Res 3:88-93, 2010. PMID 20437604. [PMC Journal – In Process]
- Rump KM, Giovannelli JL, Minshew NJ, Strauss MS: The development of emotion recognition in individuals with autism, Child Dev 80, 1434-1447, 2009. PMID: 19765010 [PMC Journal – In Process]
- Kuschner E, Bodner K, Minshew NJ: Local Versus Global Approaches to Reproducing the Rey Osterrieth Complex Figure By Children, Adolescents and Adults with High Functioning Autism. Autism Res 2(6): 348-358, 2009. PMID: 19950303 [PMC Journal – In Process]
- Hasson U, Galia A, Hagar G, Ignacio V, Harel MG, Minshew NJ, Behrmann M: Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions. Autism Res 2(5): 279-284, 2009. PMCID: PMC2775929
- Hardan AY, Pabalan M, Gupta N, Bansal R, Melhem NM, Fedorov S, Keshavan MS, Minshew NJ: Corpus callosum volume in children with autism. Psychiatry res 174(1):57-61, 2009. PMCID: PMC2761427
- Griebling J, Minshew NJ, Bodner K, Libove R, Bansal R, Konasale P, Keshavan MS, Hardan A: Dorsolateral Prefrontal Cortex Magnetic Resonance Imaging Measurements and Cognitive Performance in Autism. J Child Neurol 25(7): 856-63, 2009. PMID: 20097663 [PMC Journal - In Process]
- Gastgeb HZ, Rump KM, Best CA, Strauss MS, Minshew NJ: Prototype formation in individuals with autism: Can individuals with autism abstract a facial prototype? Autism Res 2:232-236, 2009. PMID: 19877157 [PMC Journal – In Process]
- D'Cruz AM, Mosconi MW, Steele S, Rubin LH, Luna B, Minshew NJ, Sweeney JA: Lateralized response timing deficits in autism. Biol psychiatry 66(4): 393-7, 2009. PMID: 19232577 [PMC Journal – In Process]