Associate Professor, Psychology and Psychiatry University of Pittsburgh Phone: (412) 624-8818 Fax: (412) 624-5407 Email: mfpg@pitt.edu

Ph.D., Indiana University

Research Interests

Dr. Pogue-Geile's research focuses on understanding the nature and development of genetic susceptibility to schizophrenia and the causes and structure of individual differences in neuropsychological functioning in the general population. To this end, his laboratory is engaged in studies of behavioral and neuropsychological abnormalities among relatives of schizophrenic patients. In addition, because of the developmental nature of schizophrenia, longitudinal studies of patients are also conducted. To better inform these studies of neuropsychological functioning in clinical populations, Dr. Pogue-Geile is also investigating genetic influences on neuropsychological functioning in the general population during young adulthood in a study of twins using both biometric approaches and genetic association studies with polymorphisms in genes relevant to the dopamine system.

Research and training opportunities in Dr. Pogue-Geile's laboratory include application of neuropsychology and genetic methodologies to understanding the development of susceptibility to schizophrenia. Students can receive experience in a range of neuropsychological and psychopathological assessments as applied to both normal and clinical populations, as well as experience in quantitative behavior genetic methods and genetic association and linkage methods using genetic polymorphisms.

Recent Publications

• Thompson JL, Watson JR, Steinhauer, S.R., Goldstein G, Pogue-Geile MF: Indicators of Genetic Liability to Schizophrenia: A Sibling Study of Neuropsychological Performance. Schizophr Bull 31(1): 85-96, 2005.
• Thompson JL, Pogue-Geile MF, Grace AA: Developmental Pathology, Dopamine, and Stress: A Model for the Age of Onset of Schizophrenia Symptoms. Schizophr Bull 30(4): 875-900, 2004.
• Pogue-Geile MF, Chowdari K, Wood J, Thompson J, Nimgaonkar V: Heterogeneity of schizophrenia: A genetic association study of variation in cognitive function and chromosome 13 markers. Schizophr Res 60: 89, 2003.
• Pogue-Geile MF:  Spectrum Disorders. In Encyclopedia of the Human Genome, Nature Publishing Group, 2003.
• Pogue-Geile MF, Gottesman II: Schizophrenia: Study of a genetically complex phenotype. In B.C. Jones & P. Mormède (Eds.), Neurobehavioral Genetics: Methods and applications (2nd ed). Boca Raton, FL: CRC Press.
• MacDonald AW, Pogue-Geile MF, Johnson MK, Carter CS: A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Arch Gen Psychiatry 60: 57-65, 2003.
• Pogue-Geile MF, Manuck S, Ferrell R, Debski T: Cognitive function and dopamine transporter (DAT) genetic polymorphisms: A twin and genetic association study. Behav Genet 31: 464, 2001.
• MacDonald A, Pogue-Geile M, Debski T, Manuck S: Genetic and environmental influences on schizotypy: A community-based twin study. Schizophr Bull 27: 47-58, 2001.
• Craver JC, Pogue-Geile MF: Liability to schizophrenia: A sibling study of negative symptoms. Schizophr Bull 25: 827-839, 1999.