"Monocular Advantage for Face Perception Implicates Subcortical Mechanisms in Adult Humans."
Journal of Cognitive Neuroscience, Epub ahead of print:Epub Ahead of print
Mouse over here for a brief summary or click to open article in a new tab.Most of the work exploring the neural correlates of complex visual skills, such as face perception, has focused on cortical mechanisms. There is, however, substantial phylogenetic and ontogenetic evidence to support the engagement of lower-order structures (for example, subcortical regions) in such tasks. Here, we demonstrate that prestriate regions of cortex (i.e. the monocular portions of the visual pathway) are implicated in face perception, but not in car or word perception, even in adult humans. The representations mediated by these more rudimentary regions are somewhat coarse in nature, relative to cortical representations.
"Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/1 Mouse Model of Huntington's Disease."
PLoS One, 8:12
Mouse over here for a brief summary or click to open article in a new tab.Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line, R6/1 mice have fewer CAG repeats and, subsequently, a less rapid pathological decline. Compared to the R6/2 line, fewer descriptions of the progressive pathologies exhibited by R6/1 mice exist. The association between the molecular and cellular neuropathology with brain atrophy, and with the development of behavioral phenotypes remains poorly understood in many models of HD. In attempt to link these factors in the R6/1 mouse line, we have performed detailed assessments of behavior and of regional brain abnormalities determined through longitudinal, in vivo magnetic resonance imaging (MRI), as well as an end-stage, ex vivo MRI study and histological assessment.