Papers for the month of July 2013


"A high-throughput machine learning framework to detect synapses in electron microscopy images"
BioInformatics , 29(13):i9-i17

Mouse over here for a brief summary or click to open article in a new tab.Here we develop an machine-learning approach to identifying synapses in electron microscopy images. This high-throughput analysis will facilitate studies to determine how developmental, environmental, and pharmacological conditions influence synapse density and morphology.


"Evening-type military veterans report worse lifetime posttraumatic stress symptoms and greater brainstem activity across wakefulness and REM sleep"
Biological Psychology, 0:0

Mouse over here for a brief summary or click to open article in a new tab.In this study, we examined behavioral, psychological, and neural correlates of chronotype in 36 combat-exposed military veterans with varying degrees of posttraumatic stress symptomatology, employing FDG-PET to assess neural activity across wakefulness and rapid eye movement (REM) sleep.


"Neural and Hemodynamic Responses Elicited by Forelimb- and Photo-stimulation in Channelrhodopsin-2 Mice: Insights into the Hemodynamic Point Spread Function"
Cerebral Cortex, :

Mouse over here for a brief summary or click to open article in a new tab.An optogenetic (Channelrhodopsin-2) mouse model was used to investigate the spatial properties of hemodynamic responses to evoked excitatory activity of different spatial extents. The evoked laminar activity was also investigated.


"A model of motor performance during surface penetration: From physics to voluntary control "
Experimental Brain Research, 2013:1-10

Mouse over here for a brief summary or click to open article in a new tab.We present a detailed model of puncture over a time-course of approximately 1000 ms, which is fit to kinematic data from individual punctures, obtained via a simulation with high-fidelity force feedback. The model describes puncture as proceeding from purely physically determined interactions between the surface and tool, through decline of force due to biomechanical viscosity, to cortically mediated voluntary control.


"A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke."
Journal of Neuroscience Methods, 218:170-183

Mouse over here for a brief summary or click to open article in a new tab.Linking of anatomical changes to behavioral impairments remains a major challenge. We here demonstrated that sophisticated image analysis can help to localize changes in the brain that correlate with behavioral deficits.


"Selective Effects of Baclofen on Use-Dependent Modulation of GABAB Inhibition after Tetraplegia"
The Journal of Neuroscience, 33(31):12898 –12907:12898 –12907

Mouse over here for a brief summary or click to open article in a new tab.Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders. The effects of baclofen on voluntary motor output are limited and not yet understood. Our results demonstrate that baclofen selectively maintains use-dependent modulation of largely subcortical but not cortical GABAB neuronal pathways after human spinal cord injury. Thus, cortical GABAB circuits may be less sensitive to baclofen than spinal GABAB circuits. This may contribute to the limited effects of baclofen on voluntary motor output in subjects with motor disorders affected by spasticity.


"Synchronisation hubs in the visual cortex may arise from strong rhythmic inhibition during gamma oscillations"
European Journal of Neuroscience, 10.1111/ejn.12287:1-20

Mouse over here for a brief summary or click to open article in a new tab.By examining visual responses from cat area 17 we found that, during gamma oscillations, there was a positive correlation between each unit’s sharpness of orientation tuning, strength of oscillations, and propensity towards synchronisation with other units. Using a computational model, we demonstrated that heterogeneity in the strength of rhythmic inhibitory inputs can account for the correlations between these three properties. Neurons subject to strong inhibition tend to oscillate strongly in response to both optimal and suboptimal stimuli and synchronise promiscuously with other neurons, even if they have different orientation preferences.


"Individual A-scan signal normalization between two spectral domain optical coherence tomography devices"
Investigtive Ophthalmology and Visual Science, 5:3463

Mouse over here for a brief summary or click to open article in a new tab.We developed a method to normalize optical coherence tomography (OCT) signal profiles from two spectral-domain (SD) OCT devices so that the comparability between devices increases.