Papers for the month of December 2014


Jouhanneau JS, Ferrarese L, Estebanez L, Audette NJ, Brecht M, Barth AL, Poulet JFA.

"Cortical fosGFP Expression Reveals Broad Receptive Field Excitatory Neurons Targeted by POm"
Neuron, 84(5):1065-78

Mouse over here for a brief summary or click to open article in a new tab.Here we used activity-dependent gene expression to identify a subset of layer 2 pyramidal neurons in somatosensory cortex that have broad receptive field properties. Paired, whole-cell patch clamp recordings in vivo show that fosGFP expressing neurons exhibit larger and shorter-latency synaptic responses than neighboring unlabeled cells during multi- but not single whisker stimulation. These broad receptive fields may be generated by direct thalamic input from Pom.


Wodlinger B, Downey JE, Tyler-Kabara EC, Schwartz AB, Boninger ML

"Ten-dimensional anthropomorphic arm control in a human brain-machine interface: difficulties, solutions, and limitations"
Journal of Neural Engineering, 12:016011

Mouse over here for a brief summary or click to open article in a new tab.This paper describes 10 dimensional (3D translation, 3D orientation, and 4D hand-shaping) control of a prosthetic limb by a person with tetraplegia using neural activity recorded from intracortical microelectrode arrays. We found that the presence of objects during calibration enhanced successful shaping of the prosthetic hand as it closed around the object during grasping.


Kozai T.D.Y., Li X., Bodily L.M., Caparosa E.M., Zenonos G.A., Carlisle D.L. Friedlander R.M.

"Effects of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response"
Biomaterials, 35:9620–9634

Mouse over here for a brief summary or click to open article in a new tab.Caspase-1 plays critical and relevant roles in neuronal cell death and activation of inflammatory pathways. Here we show that caspase-1 plays an important role in the biological failure mode of chronically implanted microelectrodes and that the inhibition of caspase-1 improves chronic recording performance.


Leckie, R., Oberlin L., Voss, M., Prakash, R., Szabo-Reed, A., Chaddock-Heyman, L., Phillips, S., Gothe, N., Mailey, E., Vieira-Potter, V., Martin, S., Pence, B., Lin, M., Parasuraman, R., Greenwood, P., Fryxell, K., Woods, J., McAuley, E., Kramer, A.

"BDNF mediates improvements in executive function following a 1-year exercise intervention"
Frontiers in Human Neuroscience, 8:985

Mouse over here for a brief summary or click to open article in a new tab.The present study examined BDNF as a mediator of the effects of a 1-year walking intervention on executive function in 90 older adults (mean age = 66.82). We found that age moderated the effect of intervention group on changes in BDNF levels, with those in the highest age quartile showing the greatest increase in BDNF after 1-year of moderate intensity walking exercise (p = 0.036). These results demonstrate that both age and BDNF serum levels are important factors to consider when investigating the mechanisms by which exercise interventions influence cognitive outcomes, particularly in elderly populations.


Brunet, N., Li, Y., Konecky, R., Pyles, J., Walls, S., Destefino, V., Wand, W., Richardson, R.M.

"Dynamic encoding of face information in the human fusiform gyrus"
Nature Communications, 5:5672

Mouse over here for a brief summary or click to open article in a new tab.Our study examines the dynamics of face information processing in the human fusiform face area. Specifically, we recorded from 4 patients with electrodes implanted in the fusiform for standard-of-care for surgical treatment of epilepsy. We used methods from machine learning to decode the multi-timepoint pattern (MTPA, multi-timepoint pattern analysis) of the activity. The results of these experiments demonstrate that, within 75 ms of presentation, FFA activity encodes the presence of a face (face detection), between 200 and 450 ms FFA activity encodes which face it is (face individuation), and late (500+ ms) broadband gamma FFA activity encodes task-related information about faces. These results demonstrate the dynamic contribution of FFA to multiple, temporally distinct face processing stages.


Gershon, P., Lee, R.

"Handedness in a Virtual Haptic Environment: Assessments from Kinematic Behavior and Modeling"
Acta Psychologica, 155:37-42

Mouse over here for a brief summary or click to open article in a new tab.This study evaluated hand asymmetries in performance of a dexterous, controlled task under haptic feedback.


Stanhope S., Swigon D.

"Identifiability of linear and linear-in-parameters dynamical systems from a single trajectory"
SIAM Journal of Applied Dynamical Systems, 13:1792-1815

Mouse over here for a brief summary or click to open article in a new tab.We derive necessary and sufficient conditions for the parameters of certain types of dynamical systems to be uniquely identifiable from a single data trajectory. A useful condition relates to the geometric confinement of the trajectory, and this idea is shown to also provide information about the sensitivity of parameter estimation from discrete data.


"Teaching Kodu with Physical Manipulatives"
ACM Inroads, 5:44

Mouse over here for a brief summary or click to open article in a new tab.This paper introduces a novel set of plastic tile manipulatives for teaching children the Kodu programming language. Results of a brief pilot study with second graders are described.


J. Semedo, A. Zandvakili, A. Kohn, C. Machens

"Extracting latent structure from multiple interacting neural populations"
Neural Information Processing Systems, 27:2942-2950

Mouse over here for a brief summary or click to open article in a new tab.This work presents statistical methods for studying the activity of multiple, labeled population of neurons (e.g., simultaneous population recordings from multiple brain areas).