Papers for the month of December 2015

Chandrasekaran S, Navlakha S, Audette NJ, McCreary DD, Suhan J, Bar-Joseph Z

"Unbiased, high-throughput electron microscopy analysis of experience-dependent synaptic changes in the neocortex"
The Journal of Neuroscience, 35:16450-16462

Mouse over here for a brief summary or click to open article in a new tab.We used a semiautomated analysis of electron microscopy images for an unbiased, column-wide analysis of synapse changes. This analysis reveals new loci for synaptic change that can be verified by targeted electrophysiological investigation. This method can be used as a platform for generating new hypotheses about synaptic changes across different brain areas and experimental conditions.

Nestor, A., Plaut, D. C.

"Feature-based face representation and image reconstructions from behavioral and neural data"
PNAS, Epub ahead of print :1-10

Mouse over here for a brief summary or click to open article in a new tab.http://The reconstruction of images from neural data can provide a unique window into the content of human perceptual representations. Here, we took on the two fold talk of deriving features directly from empirical data and of using thes efeatures for facial image reconstruction.

Nau A., Murphy, M.

"Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans"
Neural Regeneration Research, 10:1717

Mouse over here for a brief summary or click to open article in a new tab.Sensory substitution devices for blindness should be considered a valuable method for studying plasticity of the central nervous system. In order for vision restoration efforts to move forward, a better understanding of the brain changes as a result of vision loss is urgently needed. Neuroimaging in combination with sensory substitution devices offers tremendous versatility to provide the answers needed when deciding on the appropriate candidates for vision restoration

Quandt, L., Cardillo, E., Chatterjee, A.

"Fronto-temporal regions encode the manner of motion in spatial language"
Neuroscience Letters, 609:171-175

Mouse over here for a brief summary or click to open article in a new tab.We investigated neural encoding of path and manner during reading. Reading phrases about the manner of motion involved fronto-temporal regions.

Marek S., Hwang K., Foran W., Hallquist MN.

"The Contribution of Network Organization and Integration to the Development of Cognitive Control"
PLOS Biology, 13(12):e1002328

Mouse over here for a brief summary or click to open article in a new tab.This study reveals that although the organization of functional brain networks remains stable during adolescence, between-network integration continues to increase, underlying maturation in cognitive control.

Nicholls FJ, Rotz MW, Ghuman H, MacRenaris KW, Meade TJ

"DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells."
Biomaterials, 77:291-306

Mouse over here for a brief summary or click to open article in a new tab.The unambiguous imaging of transplanted cells remains a major challenge to understand their biological function and therapeutic efficacy. In vivo imaging of implanted cells is reliant on tagging these to differentiate them from host tissue, such as the brain. We here characterize a gold nanoparticle conjugate that is functionalized with modified deoxythymidine oligonucleotides bearing Gd(III) chelates and a red fluorescent Cy3 moiety to visualize in vivo transplanted human neural stem cells. This DNA-Gd@Au nanoparticle (DNA-Gd@AuNP) exhibits an improved T1 relaxivity and excellent cell uptake. No significant effects of cell uptake have been found on essential cell functions. Although T1 relaxivity is attenuated within cells, it is sufficiently preserved to afford the in vivo detection of transplanted cells using an optimized voxel size. In vivo MR images were corroborated by a post-mortem histological verification of DNA-Gd@AuNPs in transplanted cells. With 70% of cells being correctly identified using the DNA-Gd-AuNPs indicates an overall reliable detection. Less than 1% of cells were false positive for DNA-Gd@AuNPs, but a significant number of 30% false negatives reveals a dramatic underestimation of transplanted cells using this approach. DNA-Gd@AuNPs therefore offer new opportunities to visualize transplanted cells unequivocally using T1 contrast and use cellular MRI as a tool to derive biologically relevant information that allows us to understand how the survival and location of implanted cells determines therapeutic efficacy.

Simon N., Wood J.

"Action-outcome relationships are represented differently by medial prefrontal and orbitofrontal cortex neurons during action execution"
Journal of Neurophysiology, 114:3374-85

Mouse over here for a brief summary or click to open article in a new tab.These data provide novel evidence that prefrontal cortex subregions encode distinct information about the relationship between actions and impending outcomes during action execution

Divito C.B., Steece-Collier K., Case D.T., Williams S.P., Stancati J.A., Zhi L., Rubio M.E., Sortwell C.E., Collier T.J., Sulzer D., Edwards R., H. Zhang H., Seal R.P.

"Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinsons Disease."
Journal of Neuroscience, 35:14983-14999

Mouse over here for a brief summary or click to open article in a new tab.In this article, loss of VGLUT3 ameliorates motor deficits in a model of Parkinsons disease. Loss of the transporter also creates a circadian-dependent increase in DA synthesis, packaging, and release.

Pasquereau, B.

"Primary motor cortex of the parkinsonian monkey: altered encoding of active movement"
Brain, 139:127-143

Mouse over here for a brief summary or click to open article in a new tab.How motor cortex activity is altered in Parkinson’s disease is poorly understood. We report abnormalities in modulation and timing of putative corticospinal neurons in the MPTP model of the disease, implying that dysfunction of such neurons plays a role in the pathophysiology of parkinsonism.

Golub, Matthew

"Internal models for interpreting neural population activity during sensorimotor control"
eLife, 2015;10.7554/eLife.10015

Mouse over here for a brief summary or click to open article in a new tab.To successfully guide limb movements, the brain takes in sensory information about the limb, internally tracks the state of the limb, and produces appropriate motor commands. It is widely believed that this process uses an internal model, which describes our prior beliefs about how the limb responds to motor commands. Here, we leveraged a brain-machine interface (BMI) paradigm in rhesus monkeys and novel statistical analyses of neural population activity to gain insight into moment-by-moment internal model computations. We discovered that a mismatch between subjects' internal models and the actual BMI explains roughly 65% of movement errors, as well as long-standing deficiencies in BMI speed control. We then used the internal models to characterize how the neural population activity changes during BMI learning. More broadly, this work provides an approach for interpreting neural population activity in the context of how prior beliefs guide the transformation of sensory input to motor output. - See more at:"


  • 2017
  • 2016
  • 2015
  • 2014
  • 2013