Papers for the month of May 2016


Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Luo L, McNab J, Deisseroth K

"Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences"
Cell, 165 :1–13

Mouse over here for a brief summary or click to open article in a new tab.Appetitive or aversive experience is captured by distinct neural ensembles in mouse prefrontal cortex that are also distinguished by anatomical projection targets. Using the activity-dependent gene promoter c-fos to drive channelrhodopsin expression, reactivation of these specific ensembles can drive place preference in behaving animals.


Uyar, F., Greenberg, A., Shomstein, S.

"Retinotopic information interacts with category selectivity in human ventral cortex."
Neuropsychologia, 2016 May 27. pii: S0028-3932(16)30173-7. doi: 10.1016/j.neuropsychologia.2016.05.022.:1-12

Mouse over here for a brief summary or click to open article in a new tab.Until recently, the general consensus with respect to the organization of ventral visual cortex is that early, retinotopic regions are sensitive to the spatial position of the input stimuli whereas later, higher-order regions are sensitive to the category of the input stimuli. Growing recognition of the bidirectional connectivity of the visual system has challenged this view and recent empirical evidence suggests a more interactive and graded system. Here, based on findings from functional MRI in adult observers, in which meridians and category selective regions are localized and their activation sampled, we support this latter perspective by showing that category effects are present in retinotopic cortical areas and spatial position effects are present in higher-order regions. Furthermore, the results indicate that the retinotopic and later areas are functionally connected suggesting a possible mechanism by which these seemingly disparate effects come to be intermixed in both early and later regions of the visual system.


Jagadisan, Uday

"Disruption of Fixation Reveals Latent Sensorimotor Processes in the Superior Colliculus"
The Journal of Neuroscience, 36:6129-6140

Mouse over here for a brief summary or click to open article in a new tab.We show that transient perturbation of fixation has a long-lasting effect on sensorimotor transformation. Sensory responses of superior colliculus neurons to targets presented well after fixation perturbation are enhanced and often lead to premature movements mimicking lack of impulse control. Our findings support the notion of a common pathway for sensory and movement processing and suggest that impulsive movements arise when sensory processes become “motorized.”


Corbit, V., Whalen, T., Zitelli, K., Crilly, S., Rubin, J.

"Pallidostriatal Projections Promote β Oscillations in a Dopamine-Depleted Biophysical Network Model"
The Journal of Neuroscience, 36:5556

Mouse over here for a brief summary or click to open article in a new tab.This study uses slice physiology to show that the palliostriatal projection preferentially synapses on fast-spiking interneurons. Using a biophysical computational model, we show that this GPe projection is essential for increased beta oscillations in the dopamine-depleted pallidostriatal circuit because it causes synchronized beta-frequency pauses in striatal interneurons.


Rossetti, T., Nicholls, F.

"Intracerebral cell implantation: Preparation and characterization of cell suspensions"
Cell Transplantation, 25:645-664

Mouse over here for a brief summary or click to open article in a new tab.Intracerebral cell transplantation is increasingly finding a clinical translation. However, the number of cells surviving after implantation is low (5‐10%) compared to the number of cells injected. Although significant efforts have been made with regard to the investigation of apoptosis of cells after implantation, very little optimization of cell preparation and administration has been undertaken. We therefore focused on the in vitro aspects of cell preparation of a clinical-grade human neural stem cell (NSC) line for intracerebral cell implantation by comparing different suspension vehicles and their effects on the quality of the suspension, viability of cells, membrane damage, as well as sedimentation. These results provide the basis to further investigate these preparation parameters during the intracerebral delivery of NSCs to provide an optimized delivery process that can ensure an efficient clinical translation.


Walsh, M, Paynter, C., Zhang, Y.

"Hitting the reset button: An ERP investigation of memory for temporal context"
Brain Research, 1642:524-531

Mouse over here for a brief summary or click to open article in a new tab.In this study, we examined whether the FN400, an ERP correlate of familiarity, is sensitive to the temporal context in which an image appeared. We found that the FN00 was sensitive to whether the image had appeared in the same or a different temporal context.


Corbit V, Whalen T, Zitelli K, Crilly S, Gittis A

"Pallidostriatal Projections Promote Beta Oscillations in a Dopamine-Depleted Biophysical Network Model"
The Journal of Neuroscience, 36:5556-5571

Mouse over here for a brief summary or click to open article in a new tab.We show that pallidostriatal projections preferentially target interneurons in mouse. Incorporating this information and other earlier data on changes under dopamine depletion into a computational model, we observe and investigate the emergence of enhanced beta oscillations and synchrony under simulated dopamine-depleted conditions in the palldostriatal circuit consisting of neurons in the globus pallidus external segment, striatal medium spiny projection neurons, and stratal fast spiking interneurons.


Sarah M Haigh, Brian A Coffman, Dean F Salisbury

"Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis"
Clinical EEG and Neuroscience, 0:0

Mouse over here for a brief summary or click to open article in a new tab.MMN has been posited as a biomarker for presence of schizophrenia. Here we conducted a meta-analysis of MMN to simple auditory pitch and duration deviants in individuals who are at their first-episode of schizophrenia.

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