Papers for the month of July 2016


Urban-Ciecko, J.

"Somatostatin-expressing neurons in cortical networks"
Nature Reviews Neuroscience, 17(7):401-9

Mouse over here for a brief summary or click to open article in a new tab.Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons in the mammalian cortex. Here, we review recent advances in our understanding of how this class of cells can control network activity, with specific reference to how this is constrained by their anatomical and electrophysiological properties.


Murphy MC, Conner IP, Teng C, Lawrence JD, Safiullah Z, Wang B, Bilonick RA, Kim SG, Wollstein G, Schuman JS

"Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma"
Scientific Reports, 6:31464

Mouse over here for a brief summary or click to open article in a new tab.This study showed evidence that glaucoma deterioration is already present in the eye and the brain before vision loss can be detected clinically using current testing methods. In addition, cortical cholinergic abnormalities are involved during trans-neuronal degeneration and can be detected non-invasively in glaucoma.


Douglas Ruff

"Attention Increases Spike Count Correlations Between Visual Cortical Areas"
Journal Neuroscience, 36:7523-7534

Mouse over here for a brief summary or click to open article in a new tab.Visual attention dramatically improves the perception of attended stimuli. Attention has long been thought to act by selecting relevant visual information for further processing. It has been hypothesized that this selection is accomplished by increasing communication between neurons that encode attended information in different cortical areas. We recorded simultaneously from neurons in primary visual cortex and the middle temporal area while rhesus monkeys performed an attention task. We found that attention increased shared variability between neurons in the two areas and that attention increased the effect of microstimulation in V1 on the firing rates of MT neurons. Our results provide support for the hypothesis that attention increases communication between neurons in different brain areas on behaviorally relevant timescales.


Rich M.T., Abbot T.B., Chung L., Gulcicek E.E., Stone K.L., Colangelo C.M., Lam T.T., Nairn A., Taylor J.R., Torregrossa M.M.

"Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation"
The Journal of Neuroscience, 36(29):7589-7600

Mouse over here for a brief summary or click to open article in a new tab.This study identifies phosphorylation events that are bidirectionally regulated by the reconsolidation versus extinction of a cocaine-associated memory, including a novel site on CaMKIIα. Furthermore, we show that CaMKII inhibition in the amygdala can reduce relapse-like behavior in a rodent model of addiction.


"Gaining Mechanistic Insights into Cell Therapy Using Magnetic Resonance Imaging"
Current Stem Cell Reports, 2:221

Mouse over here for a brief summary or click to open article in a new tab.Cell therapy remains a promising approach to treat neurological disorders with evidence of clinical efficacy emerging. However, the mechanisms underlying recovery and the conditions to achieve therapeutic success are poorly understood. Uncovering putative mechanisms and their interaction is essential to progress cell therapy from an interesting and promising possibility to a robust and consistent treatment that can be used to treat large cohorts of patients. Although there is a heavy focus on stem cell biology, relatively little effort has been dedicated to understanding the in vivo mechanisms that underlie efficacy. In vivo imaging and the development of appropriate biomarkers will be essential to gain a better mechanistic understanding of cell therapy in the treatment of neurological disease. The availability of magnetic resonance imaging in a clinical setting and its use in animal models allow for its use as a unique platform for mechanistic studies of cell therapy in a translational context.


Luna B., Calabro F.

"The role of experience in adolescent cognitive development: integration of executive, memory, and mesolimbic systems. "
Neuroscience & Biobehavioral Reviews, In-Press:n/a

Mouse over here for a brief summary or click to open article in a new tab.We describe emerging research demonstrating the refinement of adolescents’ ability to integrate prior experiences to support goal-oriented behavior, which parallel hippocampal-prefrontal integration. Further, we relate the development of this circuit with known increases in dopaminergic neuromodulation in adolescence.


Michele A. Bertocci, Genna Bebko, Amanda Dwojak, Satish Iyengar, Cecile D Ladouceur, Jay C. Fournier, Amelia Versace, Susan B. Perlman, Jorge R.C. Almeida, Michael J Travis, Mary Kay Gill, Lisa Bonar, Claudiu Schirda, Vaibhav A. Diwadkar, Jeffrey L. Sunshine, Scott K. Holland, Robert A. Kowatch, Boris Birmaher, David Axelson, Sarah M. Horwitz, Thomas Frazier, L. Eugene Arnold, Mary A. Fristad, Eric A. Youngstrom, Robert L. Findling, Mary L. Phillips

"Longitudinal Relationships Among Activity in Attention Redirection Neural Circuitry and Symptom Severity in Youth"
Biological Psychiatry CNNI, In press online:In press online

Mouse over here for a brief summary or click to open article in a new tab.Examined changes in neural circuitry function that may be associated with longitudinal changes in psychiatric symptom severity in the Longitudinal Assessment of Manic Symptoms (LAMS) cohort.


Wang, Y

"Multiple timescale mixed bursting dynamics in a respiratory neuron model"
Journal of Computational Neuroscience, 10.1007/s10827-016-0616-6:1-24

Mouse over here for a brief summary or click to open article in a new tab.We analyze the mechanisms underlying a mixed bursting activity pattern seen in respiratory neurons in the pre-Botzinger complex. Mixed bursting involves transitions between two distinct bursting patterns, suggesting the involvement of processes on three disparate timescales, yet we show that un recent models, these can be produced robustly with only two distinct timescales involved.


Sarah M. Haigh, Brian A. Coffman, Timothy K. Murphy, Christiana D. Butera, Dean F. Salisbury

"Abnormal auditory pattern perception in schizophrenia"
Schizophrenia Research, 0:0

Mouse over here for a brief summary or click to open article in a new tab.Investigating complex MMN in individuals with long-term schizophrenia. The late complex MMN was reduced in schizophrenia suggesting deficits in later auditory processing.


Vinod Sharma

"Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate"
Psychiatry Research: Neuroimaging, 255:24-34

Mouse over here for a brief summary or click to open article in a new tab.Lifetime use of cannabis was assessed using multiple longitudinal interviews during adolescence and young adulthood and related to whole brain voxel-based morphometry. Reduction of volume was seen in the lingual gyrus, anterior cingulum and the right operculum. The right anterior cingulum showed the most pronounced effect which was related to variation in the cannabinoid receptor gene (CNR1. The results suggest a gene by exposure effect.


Snyder, A.C., Morais, M.J.

"Dynamics of excitatory and inhibitory networks are differentially altered by selective attention."
Journal of Neurophysiology, 0:0

Mouse over here for a brief summary or click to open article in a new tab.We found that inhibitory neurons had both greater increases in firing rate and decreases in correlated variability with attention when compared to excitatory neurons. This provides important information about how these two fundamental modes of neuronal interaction combine to support the process of attention.


J Muraskin, J. Sherwin, G. Lieberman, J. O. Garcia, T., J. M. Vettel, P. Sajda

""Fusing multiple neuroimaging modalities to assess group differences in perception-action coupling.""
Proceedings of the IEEE, 0:1-18

Mouse over here for a brief summary or click to open article in a new tab.We report a method for fusing EEG, fMRI, and DTI into a singular measure of macroscopic brain networks that identifies both structural and functional differences between experts and novices during perception-action coupling.


J. Muraskin, S. Dodhia, G. Lieberman, J. O. Garcia, J. M. Vettel, J. Sherwin, Paul Sajda

""Brain dynamics of post-task resting state are influenced by expertise: insights from baseball players." "
Human Brain MApping, 7(3):e32532

Mouse over here for a brief summary or click to open article in a new tab.We identify a network of regions connected to the SMA that associate with functional (post-task resting state) and structural differences between baseball players and matched controls.


Ramkumar P., Acuna D.E., Berniker M., Grafton S.T., Kording K.P.

"Chunking as the result of an efficiency computation trade-off"
Nature Communications, 7:12176

Mouse over here for a brief summary or click to open article in a new tab.We show that monkeys learning a reaching sequence over an extended period of time improve movement efficiency by performing movements in "chunks" that can be described as locally optimal trajectories. This occurs at the cost of increased computational complexity. Chunking can thus be understood as a cost-effective strategy for producing and learning efficient movements.

Archive:

  • 2017
  • 2016
  • 2015
  • 2014
  • 2013