Papers for the month of September 2016

O'Connell C., Ho L.C., Murphy M.C., Conner I.P., Wollstein G., Cham R.

"Structural and functional correlates of visual field asymmetry in the human brain by diffusion kurtosis MRI and functional MRI"
NeuroReport, 27(16):1225-1231

Mouse over here for a brief summary or click to open article in a new tab.Human visual performance has been observed to show superiority in localized regions of the visual field across many classes of stimuli. However, the underlying neural mechanisms remain unclear. This study suggested the structural and functional brain involvements in the asymmetry of visual field responses in humans, and is important to the neurophysiological and psychological understanding of human visual information processing.

Dr. Caterina Rosano, Dr. Enrico Novelli

"Can Neuroimaging Markers of Vascular Pathology Explain Cognitive Performance in Adults with Sickle Cell Anemia? A Review of the Literature"
Hemoglobin, 2016: 1-13

Mouse over here for a brief summary or click to open article in a new tab.Adults with homozygous sickle cell anemia have, on average, lower cognitive function than unaffected controls. The mechanisms underlying cognitive deterioration in this population are poorly understood, but cerebral small vessel disease (CSVD) is likely to be implicated. We conducted a systematic review using the Prisma Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines of articles that included both measures of cognitive function and magnetic resonance imaging (MRI) neuroimaging markers of small vessel disease. While all five studies identified small vessel disease by MRI, only two of them found a significant relationship between structural changes and cognitive performance. Differences in methodologies and small sample sizes likely accounted for the discrepancies between the studies. We conclude that while MRI is a valuable tool to identify markers of CSVD in this population, larger studies are needed to definitely establish a link between MRI-detectable abnormalities and cognitive function in sickle cell anemia.

Park, Junchol

" Impact of anxiety on prefrontal cortex encoding of cognitive flexibility."
Neuroscience, TBA:TBA

Mouse over here for a brief summary or click to open article in a new tab.In this paper, we review animal and human neurophysiological and neuroimaging studies implicating PFC neural processing in anxiety-induced deficits in cognitive flexibility. We then suggest experimental and analytical approaches for future studies to gain a better mechanistic understanding of impaired cognitive inflexibility in anxiety and related disorders

McCathern, Alexis

"Abnormal Complex Auditory Pattern Analysis in Schizophrenia Reflected in an Absent Missing Stimulus Mismatch Negativity"
Brain Topography, 29:867–874

Mouse over here for a brief summary or click to open article in a new tab.Here we show that the brain responds via a negative event-related potential called mismatch negativity to the absence of an expected event, and that this event is not due to sensory entrainment. This response is impaired in schizophrenia, suggesting a deficit in predictive coding of the auditory environment.

Lynch B., Beukema P

"Differentiating Visual from Response Sequencing during Long-term Skill Learning"
Journal of Cognitive Neuroscience, 0:1-12

Mouse over here for a brief summary or click to open article in a new tab.Training for several days on a serial order of visual cues, as opposed to a serial order of manual responses, improves learning efficiency and response binding in a sequential learning task.

Yeh F-C

"Converting Multi-Shell and Diffusion Spectrum Imaging to High Angular Resolution Diffusion Imaging"
Frontiers in Neuroscience, 10:418

Mouse over here for a brief summary or click to open article in a new tab.We show a method of reconstituting multi-shell diffusion imaging data into a single-shell format, thereby allowing any type of reconstruction method to be applied to diffusion imaging data with multiple b-values.


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