Papers for the month of November 2016


Heeger, D. J., Dinstein, I.

"Vision as a beachhead"
Biol Psychiatry., pii: S0006-3223(16)32855-4. [Epub ahead of print] Review. PMID: 27884424:32855-4

Mouse over here for a brief summary or click to open article in a new tab.http://When neural circuits develop abnormally due to different genetic deficits and/or environmental insults, neural computations and the behaviors that rely on them are altered. Computational theories that relate neural circuits with specific quantifiable behavioral and physiological phenomena, therefore, serve as extremely useful tools for elucidating the neuropathological mechanisms that underlie different disorders. The visual system is particularly well suited for characterizing differences in neural computations; computational theories of vision are well established, and empirical protocols for measuring the parameters of those theories are well developed. We review how psychophysical and neuroimaging measurements from human subjects are being used to test hypotheses about abnormal neural computations in autism, with an emphasis on hypotheses regarding potential excitation/inhibition imbalances.


Zhang, Y

"A control-theoretic approach to brain-computer interface design"
American Control Conference (ACC), 2016:5765-5771

Mouse over here for a brief summary or click to open article in a new tab.Brain-computer interfaces (BCIs) have the potential to restore motor abilities to paralyzed individuals. To construct a BCI, a mapping must be specified that dictates how neural activity will actuate a device. How should these mappings be constructed to maximize user performance? Here we forward an approach to the BCI design problem using ideas from optimal control theory.


Lindsay, Emily K.

"Mechanisms of Mindfulness Training: Monitor and Acceptance Theory (MAT)"
Clinical Psychology Review, 51:48-59

Mouse over here for a brief summary or click to open article in a new tab.We describe a new theory explaining how the components of mindfulness--attention monitoring and acceptance--interact to impact a broad range of cognitive, affective, and health outcomes observed in the mindfulness literature.


Eles JR, Vazquez AL, Snyder NR, Lagenaur C, Murphy MC, Kozai TDY, Cui XC

"Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy"
Biomaterials, 113:279

Mouse over here for a brief summary or click to open article in a new tab.Long-term neural electrode implants fail over time due to astrocytic and microglial scarring. By coating electrodes in the L1 cell adhesion molecule, we can modulate the microglial response to implanted devices. We show this in real-time with two-photon microscopy over the first 6 hours post-implant.


James Eles, Alberto L Vazquez, Noah R Snyder, Carl Lagenaur, Matthew C Murphy, Takashi DY Kozai, X Tracy Cui

"Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy"
Biomaterials, 117:279-292

Mouse over here for a brief summary or click to open article in a new tab.In this work, the acute microglial response to L1-coated neural probes was evaluated in vivo by implanting coated devices into the cortex of mice with fluorescently labeled microglia, and tracking microglial dynamics in vivo with multi-photon microscopy for the ensuing 6 h in order to understand the cellular mechanisms of action. After the processes made contact with the probes, microglial processes expanded to cover 47.7% of the control probes. For L1-coated probes, however, there was a statistically significant 83% reduction in microglial surface coverage.


Yang, Y., Aminoff, E., Tarr, M.

" A state-space model of cross-region dynamic connectivity in MEG/EEG"
NIPS, 29:1226-1234

Mouse over here for a brief summary or click to open article in a new tab.This paper provides a method of tracking dynamic functional connectivity across brain regions in MEG/EEG neuroimaging by combining a state-space model with source localization.


Galeotti J. Macdonald K., Wang J., Horvath S., Zhang A

"Generating an image that affords slant perception from stereo, without pictorial cues"
Diplays, 46:16-24

Mouse over here for a brief summary or click to open article in a new tab.This paper describes an algorithm for generating a planar image that when tilted provides stereo cues to slant, without contamination from pictorial gradients. Two behavioral experiments demonstrated that the algorithm generates stimuli that offer cues to slant under stereo viewing only, and not when disparities are eliminated.


Paletz, S., Rahimi, Z., Allegretti, S., & Rice, C.

"The Teams Corpus and Entrainment in Multi-Party Spoken Dialogues."
Proceedings of the 2016 Conference on Empirical Methods in Natural Language Processing, 00:1421

Mouse over here for a brief summary or click to open article in a new tab.When interacting individuals entrain, they begin to speak more like each other. We illustrate the use of our corpus as a novel resource for studying team entrainment by 1) developing and evaluating teamlevel acoustic-prosodic entrainment measures that extend existing dyad measures, and 2) investigating relationships between team entrainment and participation dominance.


Liu, A., Savya, S.

"Early odorant exposure increases the number of mitral and tufted cells associated with a single glomerulus"
The Journal of Neuroscience, 36(46):11646-11653

Mouse over here for a brief summary or click to open article in a new tab.Experience shapes neural circuits in a variety of ways, most commonly by changing the strength of activated connections. Understanding the structural changes induced by early odorant experience can provide insight into how olfactory bulb organization gives rise to efficient processing. Here, we find that odorant experience significantly increases the number of projection neurons associated with a single glomerulus, a dramatic and long-lasting structural change that may have important functional implications.


Yeh F-C, Vettel J., Singh A., Poczos B., Grafton S., Erickson K., Tseng W-Y.

"Quantifying Differences and Similarities in Whole-Brain White Matter Architecture Using Local Connectome Fingerprints"
PLoS Computational Biology, 12:e1005203

Mouse over here for a brief summary or click to open article in a new tab.We show how the local connectome is unique to an individual, but changes over time. We also explore to what degree the structure of the local connectome is impacted by genetics.


Williamson R., Cowley B., Litwin-Kumar A., Kohn, A.

"Scaling Properties of Dimensionality Reduction for Neural Populations and Network Models"
PLoS Computational Biology, 12:e1005141

Mouse over here for a brief summary or click to open article in a new tab.A major question in systems neuroscience is whether our interpretation of how neurons interact would change if we monitor orders of magnitude more neurons and for substantially more time. In this study, we analyzed population activity recorded in the brain and from spiking network models to understand how the results of dimensionality reduction scale with the amount of data available.

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