Papers for the month of August 2017


Karim T, Tudorascu DL, Butters MA, Walkers A, Aizenstein HJ

"In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder."
Translational Psychiatry, 8:e1204

Mouse over here for a brief summary or click to open article in a new tab.Severe worry includes a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field regarding the neural basis of worry. To date, no study has looked at neural patterns associated specifically with in-scanner induction and reappraisal of worry. In this study, we attempt to describe distinct components of the ‘neural phenomenology’ of worry: induction, maintenance, severity and reappraisal, by using a personalized, in-scanner worry script.


Rosenthal, G., Tanzer, M., Simony, E., Hasson, U., Avidan, G.

"Altered topology of neural circuits in congenital prosopagnosia."
Elife., 21:e25069

Mouse over here for a brief summary or click to open article in a new tab.http://An innovative inter-subject stimulus-locked brain activation approach uncovers marked topological differences in a brain network of higher-order visual regions in individuals with a congenital impairment in face recognition compared with controls.


Lingjue Li, Robert SB Clark, Mioara D Manole

"Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest"
Frontiers in Pediatrics, 5:174

Mouse over here for a brief summary or click to open article in a new tab.The goal of this review is to reveal the knowledge gaps regarding post-resuscitation cerebral blood flow disturbances in pediatric and adult patients, and ultimately to stimulate the development of cerebral goal-directed therapies for cardiac arrest. We present several methods used for assessment of cerebral perfusion and metabolism, and review the evolution of blood flow during the after cardiac arrest first in animal models and then in humans.


Reginald Caginalp

"Decision Dynamics in Groups with interacting members "
SIAM Journal on Applied Dynamical Systems, 16:1543

Mouse over here for a brief summary or click to open article in a new tab.Outlines drift diffusion theory for groups of deciders that communication decisions between one another.


Gabriel Ocker, Yu Hu, Michale Buice, Kresimir Josic, Robert Rosenbaum, Eric Shea-Brown

"From the statistics of connectivity to the statistics of spike times in neuronal networks"
Current Opinion in Neurobiology, 46:109

Mouse over here for a brief summary or click to open article in a new tab.A review paper discussing the mechanics underlying how circuit structure influences population spiking activity.


Gabriel Ocker, Yu Hu, Michale Buice, Kresimir Josic, Robert Rosenbaum, Eric Shea-Brown

"From the statistics of connectivity to the statistics of spike times in neuronal networks"
Current Opinion in Neurobiology, 46:109

Mouse over here for a brief summary or click to open article in a new tab.A review paper discussing the mechanics underlying how circuit structure influences population spiking activity.


Behrmann M.,

"The life-span trajectory of visual perception of 3D objects"
Scientific Reports, 7:1-11

Mouse over here for a brief summary or click to open article in a new tab.This work maps the life-span trajectory of fine-grained 3D representations from ages 4 to 86 years. The results show that the initial, coarse sensitivity to 3D information is refined, automatized and retained over the lifespan.


Verstynen T., Singh A., Jennings R.

"A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity."
Journal of the American Heart Association, 6:1

Mouse over here for a brief summary or click to open article in a new tab.Exaggerated blood pressure reactions to psychological stressors can be determined, in part, by a “brain phenotype” that is characterized by reliable neural activity changes in brain areas that regulate cardiovascular physiology during stressful experiences.


David Montez (First author) and Finn Calabro (second author)

"The expression of established cognitive brain states stabilizes with working memory development"
eLife, In press: eLife 2017;6:e25606 :in press

Mouse over here for a brief summary or click to open article in a new tab.Longitudinal 10 year developmental fMRI working memory study identifying how the stabilization of cognitive brain state variability is a critical mechanism underlying neurocognitive development


1. Benjamin, D. J., Berger, J. O., Johannesson, M., Nosek, B. A., Wagenmakers, E.--J., Berk, R., Bollen, K. A., Brembs, B., Brown, L., Camerer, C., Cesarini, D., Chambers, C. D., Clyde, M., Cook, T. D., De Boeck, P., Dienes, Z., Dreber, A., Easwaran, K., Efferson, C., Fehr, E., Fidler, F., Field, A. P., Forster, M., George, E. I., Gonzalez, R., Goodman, S., Green, E., Green, D. P., Greenwald, A., Hadfield, J. D., Hedges, L. V., Held, L., Ho, T.--H., Hoijtink, H., Jones, J. H., Hruschka, D. J., Imai, K., Imbens, G., Ioannidis, J. P. A., Jeon, M., Kirchler, M., Laibson, D., List, J., Little, R., Lupia, A., Machery, E., Maxwell, S. E., McCarthy, M., Moore, D., Morgan, S. L., Munafó, M., Nakagawa, S., Nyhan, B., Parker, T. H., Pericchi, L., Perugini, M., Rouder, J., Rousseau, J., Savalei, V., Schönbrodt, F. D., Sellke, T., Sinclair, B., Tingley, D., Van Zandt, T., Vazire, S., Watts, D. J., Winship, C., Wolpert, R. L., Xie, Y., Young, C., Zinman, J., & Johnson, V. E.

"Redefine Statistical Significance"
Nature Human Behavior, NA:NA

Mouse over here for a brief summary or click to open article in a new tab.In this paper, we propose to reduce the significance level to .005.


Parekh P, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y

"Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the Clockd19 Model of Bipolar Mania"
Biological Psychiatry , 17:31721

Mouse over here for a brief summary or click to open article in a new tab.Using a transgenic mouse model of bipolar mania in which the core circadian clock is disrupted, we characterized deficits in excitatory neurotransmission in a region important for mood and reward processing. We further demonstrated that upregulation of a glutamate receptor subunit in this region can normalize manic-like behaviors.


Crum WR, Gerwig M, Vernon AC, Patel P, Jackson MJ, Rose S, Jenner P, Iravani MM.

"Magnetic resonance imaging and tensor-based morphometry in the MPTP-treated non-human primate model of Parkinson disease."
PLOS One, 12:e0180733

Mouse over here for a brief summary or click to open article in a new tab.Parkinson’s disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the pivotal pathological event. To better understand the progression of PD and improve treatment management, defining the disease on a structural basis and expanding brain analysis to extra-nigral structures is indispensable. The anatomical complexity and the presence of neuromelanin, make the use of non-human primates an essential element in developing putative imaging biomarkers of PD. To this end, ex vivo T2-weighted magnetic resonance images were acquired from control and 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated marmosets. Volume measurements of the caudate, putamen, and substantia nigra indicated significant atrophy and cortical thinning. Tensor-based morphometry provided a more extensive and hypothesis free assessment of widespread changes caused by the toxin insult to the brain, especially highlighting regional cortical atrophy. The results highlight the importance of developing imaging biomarkers of PD in non-human primate models considering their distinct neuroanatomy. It is essential to further develop these biomarkers in vivo to provide non-invasive tools to detect pre-symptomatic PD and to monitor potential disease altering therapeutics


Wood, J., Simon, N., Koerner, S. Kass, R.

"Networks of VTA Neurons Encode Real-Time Information about Uncertain Numbers of Actions Executed to Earn a Reward"
Frontiers in Behavioral Neuroscience, n/a:n/a

Mouse over here for a brief summary or click to open article in a new tab.Ensembles of VTA neurons encode real time information about a series of actions.


Bittner S., Williamson R., Snyder A., Litwin-Kumar A.

"Population activity structure of excitatory and inhibitory neurons"
PLoS One, 12:e0181773

Mouse over here for a brief summary or click to open article in a new tab.Many studies use population analysis approaches, such as dimensionality reduction, to characterize the activity of large groups of neurons. To date, these methods have treated each neuron equally, without taking into account whether neurons are excitatory or inhibitory. We studied population activity structure as a function of neuron type by applying factor analysis to spontaneous activity from spiking networks and population activity recordings in the visual cortex.

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