“NEUROVASCULAR COUPLING PHYSIOLOGY AND NEURODEGENERATIVE PATHOPHYSIOLOGY”
DR. EDITH HAMEL
PROFESSOR DEPT. OF NEUROLOGY AND NEUROSURGERY
MONTREAL NEUROLOGICAL INSTITUTE (MNI) AND MCGILL UNIVERSITY
MONDAY APRIL 1, 2019 AT 1:00PM
LANGLEY HALL A219B
UNIVERSITY OF PITTSBURGH
Neurovascular coupling, the basis of brain imaging techniques that use hemodynamic signals as proxy for changes in neuronal activity, requires interactions between neurons, astrocytes and the microcirculation in order to adapt the need in glucose and oxygen to changes in neuronal activity either at baseline or following a given task or stimulus. In the cerebral cortex, depending on the stimulus, the changes in local cerebral blood flow result from activity changes in different populations of interneurons and pyramidal cells that act either directly or indirectly through perivascular astrocytes to orchestrate the resulting changes in perfusion. When cortical activity is modulated, mimicking conditions of either alertness (enhanced cholinergic tone) or pathology like Alzheimer’s disease (reduced cholinergic tone), the reliability of neurovascular coupling as a surrogate for changes in neuronal activity is altered or lost. Such unreliability is also found in animal models of dementia or cerebrovascular disease reminiscent to that of patients with vascular cognitive impairment and dementia, where age-dependent reduced hemodynamic signals fail to reflect changes in neuronal activity. Overall, the results underscore the selective role of different neuronal populations in modulating local cerebral blood flow in response to specific stimuli. Further, they highlight that caution is warranted in the use and interpretation of clinical brain imaging data in patients with cerebrovascular diseases. Funded by grants from the Canadian Institutes of Health Research (CIHR), the Alzheimer Society of Canada and the Healthy Brains for Healthy Lives (HBHL) program of McGill University.
Department of Neurobiology
Presents a Special Seminar:
“Pathobiology of neurotoxic protein inclusions in ALS and dementia”.
Christopher Donnelly, PhD
Department of Neurobiology
Live Like Lou Center for ALS Research, Brain Institute
University of Pittsburgh
Thursday, April 18, 2019
6014 Biomedical Science Tower 3
Seminar supported in part by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (T32 NS086749)
Hello, students, faculty, postdocs, and staff:
Please mark your calendars for the Department of Epidemiology’s annual Sutton-Tyrrell Lecture, which will conclude the spring 2019 Epidemiology Seminar series:
Sutton-Tyrrell Lecture date: April 18, 2019
Presentation title: ` `“Vascular Disease in Alzheimer’s and Dementia: Opportunities for Prevention”
Reception time & location: 10:45 am – 11:30 am Pitt Public Health Commons (1st floor) Refreshments will be served.
Lecture time & location: 11:30 am – 12:30 am G-23 Pitt Public Health Auditorium**
**NOTE THE CHANGED TIME FOR EPIDEMIOLOGY SEMINAR ON THE LECTURE DATE**
This year’s presenter is Carol A. Derby, PhD, Research Professor, Saul R. Korey Department of Neurology; Research Professor, Department of Epidemiology and Population Health, Albert Einstein College of Medicine.
More Sutton-Tyrrell Lecture Series information will be forwarded in the near future. On behalf of Drs. Newman and Cauley, and Drs. Kriska and Glynn, Epidemiology Seminar course directors, I hope you will plan to attend.
Panel Discussion: Neuro-Robotics
Experts in the field will discuss state of the art and where we stand on mind-controlled robotics including both noninvasive and invasive brain computer-interface approaches.
Gerry Balbier is the Executive Director of the Carnegie Mellon Neuroscience Institute (CMNI). CMNI is a cross-disciplinary neuroscience institute working to create innovative tools and technologies critical to advancing brain science and building on the success of the joint CMU/University of Pittsburgh Center for the Neural Basis of Cognition.
Jennifer Collinger, PhD, is an assistant professor in the Department of Physical Medicine and Rehabilitation at the University of Pittsburgh and a Research Biomedical Engineer at the Pittsburgh VA R&D Center of Excellence. Dr. Collinger’s research interests are related to the use of neuroprosthetics to restore function for individuals with upper limb paralysis or loss. She is developing intracortical brain-computer interface technology for individuals with tetraplegia. Her work also includes non-invasive imaging for measuring neuroplasticity after spinal cord injury or amputation.
Bin He is Department Head and Professor of Biomedical Engineering at Carnegie Mellon University. Dr. He has made significant contributions to the field of neuroengineering and biomedical imaging. His lab demonstrated for the first time for humans to control the flight of a drone by “thoughts” and pioneered the noninvasive mind-controlled robotics. Dr. He’s work has been recognized by the IEEE Biomedical Engineering Award and the Academic Career Achievement Award from the IEEE Engineering in Medicine and Biology Society.
A symposium honoring Brian MacWhinney and his influence on the fields of language acquisition and language processing will take place on June 6-8, 2019 at Carnegie Mellon University in Pittsburgh, PA. Workshops involving components of the TalkBank (talkbank.org) system, including CHILDES (childes.talkbank.org), will take place on June 6, and spoken presentations and poster sessions on TalkBanks, Emergentism, and the Competition Model on June 7th and 8th.
Join Us June 6-8, 2019 for a Symposium at Carnegie Mellon University, Pittsburgh PA, honoring Brian MacWhinney. Workshop registration, poster submissions, and conference participation are open to all. Email questions and comments to Roman Taraban firstname.lastname@example.org. Co-organizers Patricia Brooks, Rick Gilmore, Vera Kempe, Ping Li, Janet McDonald.
Follow us on twitter @MacWhiSymposium